Egas Moniz was a Portuguese neurosurgeon who
is best remembered for his contributions to the neurosurgery of the human psyche. He
received the Nobel Prize in Medicine in 1949 along with Walter Hess, a Swiss physiologist.
This prize was accorded for their development of prefrontal leucotomy, a brain operation
for the treatment of certain mental disorders. Since those early days, medications have
thankfully supplanted the need for brain surgery in the management of severe psychiatric
brain disorders.
A more important legacy was his introduction of cerebral arteriography. His authorship
is largely forgotten but arteriography remains his most important contribution. In the
early years of neurosurgery. the localization of brain abnormalities was accomplished by
neurological examination and skull x-rays. Walter Dandy introduced pneumoenecphalography,
the injection of air into the spinal and cerebral cerebrospinal fluid pathways as a way of
outlining the brain and its interior. These primitive methods remained the only
method of localizing brain abnormalities until arteriography. Fifty years later CT and MRI
scanning can accurately visualize intracranial pathology. Arteriography continues as a
method of diagnosis , and now a method for treatment. Injection of dye into cerebral
arteries and veins can outline pathological conditions. Injection of material through
these intravascular catheters can also treat many of these intracranial conditions.
Professor Moniz deserves a second Nobel Prize!